4 comments

  • BigTTYGothGF 2 hours ago
    Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...
    • adrian_b 7 minutes ago
      And various dedicated AI models all made poor predictions of the results of that experiment, which casts doubts about the value of the AlphaGenome predictive map.
  • hn1rig3rak 1 hour ago
    the catch with a genome-wide map is the benchmark labels came from conservation, so you can't tell prediction from re-reading the prior.
    • bonsai_spool 41 minutes ago
      > benchmark labels came from conservation

      And from human disease...?

  • thelaxiankey 47 minutes ago
    this is literally not possible. while I'm excited for these kinds of things, alphafold is already imperfect, and this basically side-steps actual structural predictions. it sounds good, but frankly biology is not there yet. in practice not even alpha fold can tell me if my gfp fusion will work...
  • ChrisArchitect 1 hour ago