6 comments

  • woliveirajr 1 hour ago
    Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest.

    Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor.

    Help to live longer was the main objective since the beginning.

    [0] https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History

    • joezydeco 1 hour ago
      I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation.

      And all we got was another boner pill.

      • giantg2 6 minutes ago
        Quanity and/or quality of sex shows correlation with longer lifespan. Maybe this is a roundabout way to get there...
      • fny 55 minutes ago
        Lifespans and inflammation are ironically harder problems.
        • mykowebhn 22 minutes ago
          Yes, but we don't want medical science to go soft by focusing on the easy problems.
      • fragmede 50 minutes ago
        During your extended lifetime, wouldn't you like to be able to have a boner, though?
  • jurip 43 minutes ago
    There was also just last week this study, which indicated a link to a higher risk of glaucoma: https://www.thepharmacist.co.uk/clinical/mens-health-clinica...
  • comrade1234 1 hour ago
    The weirdest thing I read about was weightlifters taking viagra to increase their blood flow when working out at the gym. Hopefully they shower at home.
    • throwawaytea 25 minutes ago
      Just an FYI, these drugs don't actually cause erections or sexual excitement. They simply make erections easier.

      Now, if someon is mildly excited by other bodybuilders but usually not enough to make it known, yes Cialis could cause 'movement' as George Costanza put it.

      But if you're not into what's in front of you, Cialis isn't going to change anything.

    • GenerWork 1 hour ago
      >weightlifters taking viagra to increase their blood flow when working out at the gym

      The weightlifting community moved off of Viagra years ago due to Cialis having a much longer half life.

  • francisofascii 57 minutes ago
    Suprised this article doesn't mention nitric oxide or vasodilation? Is that how it works. It boosts nitric oxide signaling, acts as a vasodilator, and improves endothelial function. Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.
    • josh-wrale 26 minutes ago
      I thought nitrates were dangerous with regard to cancer. (?)
  • khalic 17 minutes ago
    As usual, without double blind studies, this is playing with fire… maybe the people taking have better health because of the extra exercise that goes with an active sex life.
  • jacknews 1 hour ago
    Maybe the extra sex is the main benefit?