I am living in Poggio a Caiano and I never expect it will be mentioned on HN.
I know very well the history of Bianca Cappello and I am not surprised about the malaria. The area around Poggio a Caiano (Poggio means exactly "small hills") was a swamp and malaria was very common.
tl;dr; - Scientists did DNA testing on the remains of the Grand Duke and his wife, and found malaria. The rival theory is poisoning by the relative who was next in line for the Ducal throne. HOWEVER, this test result solves nothing:
> But is there any guarantee that Francesco was not also poisoned?
> “Perhaps not,” Ochoa said, “but the genetic evidence presented in our study decreases the margin for speculation.”
> Gisella Caccone, a senior research scientist also at Yale and a study coauthor, agrees. “We can say that they had malaria, we cannot say that they were not poisoned as well,” Caccone said in an email.
Maybe they were poisoned, had malaria, were stabbed, and also suffocated and drowned, all at the same time?
"solves" is a silly thing to ask for in matters of probability. I think this test result adds data which shifts probabilities, and that's the best we'll get.
Yes, which is why the immunological tests done in 2006 were not seen as conclusive. However, this time they found actual plasmodium DNA which suggests active infection at time of death. Including from two species, suggesting double infection. Fun.
I live in Ghana, we have malaria as a common (not too common though) ailment. I have also had malaria several times, though the last time was almost 9 years ago.
As I understand it, some malaria parasites can remain dormant in the body for a long time. Clinical symptoms develop once the parasite burden and immune response become sufficient to cause illness.
Not sure if the couple had made trips to Tuscany before the last one, but it is interesting they found two species of malaria pathogens.
I thought that was also an interesting angle to consider.
> Not sure if the couple had made trips to Tuscany before
Dude, they were the royal family of Tuscany. They lived there. Which is why this test is not conclusive: sure, they had malaria, but at the time it was pretty common in the region and they likely had it for a long time.
I too am astounded by humanities desire to know things without a monetary benefit. Don't they understand the money spent on this could've gone to a vulture capital?
Trying to be positive, there are lots of researchers in the world trying to improve forensic anthropomorphic techniques for the betterment of mankind and this is an interesting enough project to work on?
But yes, if they had malaria, does it make it their cause of death? Who knows?
I worked for a very small company getting funding by the Medici Fund a while back. First I ever heard of the name.
So much intrigue in the past. Guys like Montaigne were said to have "food tasters" to sample the goods before they ate themselves.
As a career trace analytical chemist, I can tell you for sure, that weird poisonings are so much less likely to occur now, because of the probability of detection. That's a little comforting. The same goes for the food supply. Mechanisms are in place to rapidly detect deliberately placed poisons.
My family has spent centuries marrying into an alternative claimant to the Grand Duke of Tuscany who did not inherit through Ferdinando I. We were planning to use this as an excuse to invade Italy and put the scion of our own dynasty on the throne and establish ourselves as royalty in the annals of history.
Unfortunately, this + the unification of Italy may have irredeemably foiled our plan.
Not sure what to do now, should I find a wife with a better claim?
Nah, ditch the wife. Become a cardinal in the Catholic church, then get elected pope. From there it should be fairly trivial to re-establish the Papal States to their largest extent.
You could marry your claim to an ideological framework upholding the Divine Right of Kings and traditionalist conservatism, causing it to live for centuries longer in the form of monarchy enthusiast cranks.
https://tornyol.com
> But is there any guarantee that Francesco was not also poisoned?
> “Perhaps not,” Ochoa said, “but the genetic evidence presented in our study decreases the margin for speculation.”
> Gisella Caccone, a senior research scientist also at Yale and a study coauthor, agrees. “We can say that they had malaria, we cannot say that they were not poisoned as well,” Caccone said in an email.
"solves" is a silly thing to ask for in matters of probability. I think this test result adds data which shifts probabilities, and that's the best we'll get.
Just now learning Grigori Rasputin died of malaria.
As I understand it, some malaria parasites can remain dormant in the body for a long time. Clinical symptoms develop once the parasite burden and immune response become sufficient to cause illness.
Not sure if the couple had made trips to Tuscany before the last one, but it is interesting they found two species of malaria pathogens.
I thought that was also an interesting angle to consider.
Dude, they were the royal family of Tuscany. They lived there. Which is why this test is not conclusive: sure, they had malaria, but at the time it was pretty common in the region and they likely had it for a long time.
The pragmatic answer is "if only it was that easy" -
https://en.wikipedia.org/wiki/Malaria#Immune_system_evasion
https://en.wikipedia.org/wiki/File:Global_malaria_deaths_201...
But yes, if they had malaria, does it make it their cause of death? Who knows?
I worked for a very small company getting funding by the Medici Fund a while back. First I ever heard of the name.
So much intrigue in the past. Guys like Montaigne were said to have "food tasters" to sample the goods before they ate themselves.
As a career trace analytical chemist, I can tell you for sure, that weird poisonings are so much less likely to occur now, because of the probability of detection. That's a little comforting. The same goes for the food supply. Mechanisms are in place to rapidly detect deliberately placed poisons.
Unfortunately, this + the unification of Italy may have irredeemably foiled our plan.
Not sure what to do now, should I find a wife with a better claim?
I choked on my latte
Just imagine the titles you could use.
Naah. You start an AI company!
(sorry guys channeling my ken m)