> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks.
"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:
> Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.
Cool! But please be honest in your press releases.
I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon?
We have several drugs that emulate dementia in various ways and call them recreational.
Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation
I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the system that evolves from it is actively worse than nearly any other system with a good loss function like 'health' or even just 'fame and notoriety for the scientists involved'
2.2 Animals and Study Design
The study comprised two cohorts of C57BL/6 mice: young adult (3 months old) and late middle-aged (18 months old). We chose 18 months old mice, as this mouse age is approximately equivalent to a 60-year-old human (Dutta and Sengupta 2016).
"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:
> Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.
Cool! But please be honest in your press releases.
(In mice)
We have several drugs that emulate dementia in various ways and call them recreational.
https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
I posted paper above, DOI was linked at the end.
https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...