8 comments

  • Rygian 1 hour ago
    The "surprising way" is by using a derivate of LSD.

    I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

    • lelanthran 7 minutes ago
      > The "surprising way" is by using a derivate of LSD.

      What's the difference between a derivate and a derivative?

      (I'm not being facetious, I'd really rather like to know)

    • jijijijij 12 minutes ago
      Calling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.
  • kykat 1 hour ago
    It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.
    • kubb 27 minutes ago
      Where do you go when you need to escape but can't actually go anywhere?

      Inwards. Imagination, media, substances, meditation, solitude.

    • thinkingtoilet 50 minutes ago
      Well... drugs are amazing. They're so amazing people will literally die for them.
  • throwaway12pol 1 hour ago
    Unfortunately, I will probably never be able to try that for my GAD even if they confirm the positive effects due to stigma surrounding psychoactive drugs! Yay!
  • khelavastr 10 minutes ago
    This reflects a longstanding...essentially conspiracy...to suppress attention to 5HT2A-based neural regulation because it sheds such poor light on SSRIs
  • OutOfHere 26 minutes ago
    Of course they want to repackage a cheaply synthesized substance at 100-1000x the costs even though the original likely works just as well. That's pharma for you.
  • analog8374 1 hour ago
    "Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Here's Tom with the weather."

    -Bill Hicks

    • thin_carapace 10 minutes ago
      today an evolved monkey realized that the evolution of intelligence via genetic algorithms doesnt line up that well with the scientific trajectory of existence since the big bang , he then realized that his perception of existence would be exactly equivalent to that of a brain in a jar , his final realization was that all realizations are epheremal regardless as to how convincing or conclusive they may seem
    • mrroryflint 53 minutes ago
      Thanks for reminding me of this. One of the all time greats.
    • phishin 48 minutes ago
      Tool.
      • mynameisash 15 minutes ago
        In case others don't know, Tool used this quote in their song Third Eye.
        • LgWoodenBadger 5 minutes ago
          It's more than just a quote, it's a sample of Bill Hicks himself speaking it.
  • kunley 51 minutes ago
    It is tragically funny to consider linking quietness of mind with LSD. It is everything but quiet
    • driggs 22 minutes ago
      The "neuroplasticity" which leads to a relative quietness presumably comes after the psychedelic experience.

      Interestingly, the paper only lists the following adverse effects: visual perceptual changes, nausea, and headache. Given that the patients in the double-blind study were those who suffer from moderate to severe Generalized Anxiety Disorder, I could imagine some significant anxiety in the 200 µg active group!

      The paper only reports significant results at the 100 µg and 200 µg dose level, not less, which seems like another strike against psychedelic microdosing. The pharmaceutical industry would love to find a magic psychedelic drug which doesn't result in the psychedelic experience, but it seems like that experience is the key to their mental impact.

  • PowerElectronix 33 minutes ago
    "Side effects were mild or moderatr and included hallucinations..."

    Yeah....

    • OutOfHere 27 minutes ago
      No. That is a gross and deliberate mischaracterization in bad faith. Here is the full quote:

      > Side effects were generally mild or moderate and included hallucinations, visual distortions, nausea, and headache. It's important to note, these were more prevalent using the highest dosage -- which we will not be using since it was found to be no more effective.